Portfolio
Accelerating Success

Nuvig
Nuvig Therapeutics is advancing transformational therapies that are designed to induce natural mechanisms to restore immune homeostasis and rebalance immune function in autoimmune and chronic inflammation diseases.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2021 |
| Visit: | www.nuvigtherapeutics.com/ |

Invenio
Revolutionizing intraoperative histology with their NIO Laser Imaging System and AI-powered image analysis.
| Industry: | Diagnostics |
| Status: | Active |
| Initial Investment: | 2015 |
| Visit: | https://www.invenio-imaging.com/ |

Mediar Therapeutics
Mediar Therapeutics is drugging the myofibroblast as a new approach to halt and reverse fibrosis.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2019 |
| Visit: | https://www.mediartx.com/ |

Jupiter
Jupiter Bioventures LLC is a company creation engine – focused on de-risking early-stage projects.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2021 |
| Visit: | www.jupiter.bio/ |

Mammoth Biosciences
Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products.
| Industry: | Diagnostics |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://mammoth.bio/ |

Kit
Kit offers comprehensive at-home health & lab testing solutions.
| Industry: | Diagnostics |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://www.kit.com/ |

March Biosciences
March Bio is a clinical stage company advancing novel cell therapies for T-cell malignancies.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2024 |
| Visit: | march.bio |

Eikonizo Therapeutics
Eikonizo is developing brain penetrant and peripherally-restricted small molecule HDAC6 inhibitors to improve the treatment of human disease.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2023 |
| Visit: | www.eikonizo.com |

Arkuda Therapeutics
Arkuda Therapeutics is advancing novel targeted medicines for the treatment of frontotemporal dementia.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2019 |
| Visit: | https://www.arkudatx.com/ |

Nobell Foods
Unlocking the power of plants to create the next generation of animal-based food substitutes.
| Industry: | Consumer Products |
| Status: | Active |
| Initial Investment: | 2019 |
| Visit: | https://www.nobellfoods.com/ |

Cavalry Biosciences
CAVALRY Biosciences is developing novel therapeutics by engineering tissue-selective growth factors and cytokines to harness their potent biology and build better treatments for both rare and chronic diseases.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2024 |
| Visit: | www.cavalry.bio |

Calithera
Calithera is developing first-in-class small molecule drugs directed against tumor metabolism and tumor immunology targets to treat cancer.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2010 |
| Visit: | https://www.calithera.com/ |

Photoswitch
Photoswitch is creating advanced tools to drive next-generation membrane biology discoveries.
| Industry: | Lab Tools |
| Status: | Exited |
| Initial Investment: | 2017 |
| Visit: | http://photoswitchbiosciences.com/ |

Bolt Threads
Bolt Threads is a material solutions company inspired by nature to develop materials for a more sustainable future.
| Industry: | Consumer Products |
| Status: | Active |
| Initial Investment: | 2011 |
| Visit: | https://boltthreads.com/ |

Progentos Therapeutics
Progentos is developing a new approach to treating multiple sclerosis that stimulates the body’s natural repair mechanisms.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2024 |
| Visit: | www.progentos.com |

QurAlis
QurAlis is developing breakthrough precision medicines for ALS and other neurologic diseases.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://quralis.com/ |

Comet Therapeutics
Comet Therapeutics is built an engineering platform to address unmet medical needs from inborn errors of metabolism.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2019 |
| Visit: | http://comettherapeutics.com/ |

Ambagon Therapeutics
Ambagon is drugging the undruggable by manipulating interactions with the adaptor protein 14-3-3.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2020 |
| Visit: | https://ambagontx.com/ |

Epiodyne
Epiodyne is developing breakthrough medicines to provide patients with safe options to break their opioid dependence, fight the spread of opioid use disorders, and provide non-addictive pain relief.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2016 |
| Visit: | https://epiodyne.com/ |

Applaud Medical
Applaud Medical aims to improve treatment methods, patient experiences and medical costs for all patients experiencing the effects of kidney stones.
| Industry: | Devices |
| Status: | Active |
| Initial Investment: | 2015 |
| Visit: | https://applaudmedical.com/ |

Circle Pharma
Circle Pharma operates an indication-agnostic discovery engine for the development of cell permeable macrocyclic peptide therapeutics.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2013 |
| Visit: | https://circlepharma.com/ |

Myka Labs
Myka Labs is pioneering a magnetic and minimally invasive surgical device to allow complex GI tract interventions.
| Industry: | Devices |
| Status: | Active |
| Initial Investment: | 2011 |
| Website | https://myka.bio/ |

ARase Therapeutics
ARase Therapeutics is developing first-in-class inhibitors that target cancer signaling pathways.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2021 |
| Visit: | https://arasetherapeutics.com/ |

Symbiome
Leveraging proprietary microbiome research to develop products that naturally promote the clarity, vibrance, and resilience of skin.
| Industry: | Consumer Products |
| Status: | Active |
| Initial Investment: | 2017 |
| Visit: | https://www.symbiome.com/ |

Redwood Bioscience
Redwood Bioscience’s novel, site-specific protein conjugation and linker technologies enable the generation of homogenous bioconjugates with enhanced safety, stability, and potency. Acquired by Catalent Pharma Solutions in 2014.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2010 |

Vaxess
Vaxess Technologies is transforming delivery of vaccines and therapeutics through the MIMIX patch, making vaccines more effective and accessible.
| Industry: | Drug Delivery |
| Status: | Active |
| Initial Investment: | 2016 |
| Visit: | https://www.vaxess.com/ |

Atreca
Atreca inverts the traditional antibody discovery paradigm by using active patient B cell responses to discover functional human antibodies and access novel target biology. IPO in June 2019 (NASDAQ: BCEL).
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2012 |
| Visit: | https://www.atreca.com/ |

Nocion Therapeutics
Nocion Therapeutics is revolutionizing the treatment of neurogenic inflammation by silencing inflamed nociceptors.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://www.nociontx.com/ |

Vivace Therapeutics
Vivace Therapeutics is an oncology-focused small molecule drug discovery and development company.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2015 |
| Visit: | https://vivacetherapeutics.com/ |

Dren bio
Dren reprograms natural killer cells to attack cancer cells by leveraging antibody-dependent cellular cytotoxicity.
| Industry: | Therapeutics |
| Status: | Partial Exit |
| Initial Investment: | 2019 |
| Visit: | https://www.drenbio.com/ |

Principia Biopharma
Principia Biopharma develops covalent Bruton tyrosine kinase (BTK) inhibitors for the treatment of autoimmune diseases. Acquired by Sanofi in 2020.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2011 |
| Visit: | https://www.principiabio.com/ |

Avexegen
Avexegen is developing novel therapies to promote and restore gut health.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2016 |
| Visit: | http://www.avexegen.com/ |

Wildtype
Starting with sushi-grade salmon, Wildtype is pioneering cellular agriculture to grow delicious cuts of our favorite seafood.
| Industry: | Agriculture and Climate |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://www.wildtypefoods.com/ |

Fluxion
Fluxion Biosciences develops microfluidic tools for cellular analysis and liquid biopsy tests.
| Industry: | Lab Tools |
| Status: | Active |
| Initial Investment: | 2011 |
| Visit: | https://www.fluxionbio.com/ |

AI Proteins
AI Proteins is a biotech company on a mission to re-imagine protein therapeutics with a novel approach for designing entirely new proteins. Using AI-enabled design and a high-throughput drug discovery platform, AI Proteins creates de novo miniproteins optimized for a variety of therapeutic applications.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2025 |
| Visit: | http://aiproteins.bio/ |

Sound
Sound Agriculture is creating a more agile and resilient food system with innovative on-demand crop solutions.
| Industry: | Agriculture |
| Status: | Active |
| Initial Investment: | 2017 |
| Visit: | https://www.sound.ag/ |

Asherbio
Founded by Mission BioCapital, Arclight is building a portfolio of neurodegeneration companies to accelerate transformative neuroscience.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2020 |
| Visit: | https://asherbio.com/ |

Zephyrus Biosciences
Zephyrus Biosciences is a research tool company developing single cell western blot system for protein analysis. Acquired by Bio-Techne in 2016.
| Industry: | Lab Tools |
| Status: | Exited |
| Initial Investment: | 2014 |
| Website: | http://www.zephyrusbio.com/ |

ImmunOs
ImmunOs Therapeutics is developing the next generation of immunomodulatory therapies that have a role in the innate immune system for cancer and autoimmune diseases.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2022 |
| Visit: | www.immunostherapeutics.com/ |

Symic Bio
Symic Biomedical is developing therapeutics for fibrotic diseases by targeting the extracellular matrix.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2014 |
| Visit: | http://www.symic.bio/ |

SiteOne
SiteOne is developing a completely new class of non-opioid treatments for pain which selectively interrupt electrical signals from hyperexcitable, peripheral sensory nerves before they engage the central nervous system. Acquired by Eli Lilly in 2025
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2014 |
| Visit: | https://www.siteonetherapeutics.com/ |

Effector
Pioneering the discovery and development of selective translation regulator inhibitors to harness the body’s ability to fight disease.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2013 |
| Visit: | https://effector.com/ |

Shape Therapeutics
Shape Therapeutics is harnessing the potential of RNA therapeutics to shape the future of gene therapy.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2018 |
| Visit: | https://shapetx.com/ |

Vedere
Vedere aims to restore vision in patients with photoreceptor-based vision loss. Vedere was acquired by Novartis in 2020.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2019 |
| Visit: | https://vederebio.com/ |

LogicInk
LogicInk is a lifestyle sensor company, developing bio-chemical Signals that can be worn or applied daily.
| Industry: | Diagnostics |
| Status: | Active |
| Initial Investment: | 2017 |
| Visit: | https://logicink.com/ |

Caribou Biosciences
Caribou is focused on developing genome-edited allogeneic cell therapies for devastating human diseases. IPO in July 2021 (NASDAQ: CRBU)
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2014 |
| Visit: | https://www.cariboubio.com/ |

Magnap
Magnap is developing a minimally-invasive surgical device to prevent airway collapse during sleep.
| Industry: | Devices |
| Status: | Active |
| Initial Investment: | 2013 |
| Visit: | https://magnapsleepapnea.net/ |

Sensorium Therapeutics
Sensorium Therapeutics is a clinical stage biotechnology company developing brain and mental health treatments that are derived from nature, mechanistically driven, clinically precise, and designed to help people thrive.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2025 |
| Visit: | https://www.sensorium.bio/ |

Alector
Harnessing the immune system to cure neurodegenerative disease. IPO in February, 2019 (NASDAQ: AEC)
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2015 |
| Visit: | https://alector.com/ |

Glycomine
Developing therapies for patients with rare diseases of protein and lipid glycosylation.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2019 |
| Visit: | https://glycomine.com/ |

Nitrase Therapeutics
Developing a new class of medicines based on breakthrough discoveries in enzyme biology.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2020 |
| Visit: | http://nitrasetx.com/ |

Tune Therapeutics
Tune Therapeutics is developing next-generation cell-therapies using their platform of targeted epigenetic modifiers.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2021 |
| Visit: | https://tunetx.com/ |

Tangible Science
Tangible Science is committed to creating products to make a more comfortable contact lens.
| Industry: | Consumer Products |
| Status: | Active |
| Initial Investment: | 2013 |
| Visit: | https://tangiblescience.com/ |

Alessa Therapeutics
Alessa Therapeutics is focused on development, clinical validation and commercialization of local, sustained drug delivery for solid tumors.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2019 |
| Visit: | https://www.alessatherapeutics.com/ |

Pionyr Immunotherapeutics
Pionyr Immunotherapeutics is developing cancer immunotherapies that target the tumor microenvironment to enhance the body's antitumor response. Acquired by Gilead Sciences in 2020.
| Industry: | Therapeutics |
| Status: | Exited |
| Initial Investment: | 2016 |
| Visit: | https://www.pionyrtx.com/ |

Zymergen
Zymergen is a synthetic biology company creating materials for a variety of applications. IPO in April 2021 (NASDAQ: ZY).
| Industry: | Consumer Products |
| Status: | Exited |
| Initial Investment: | 2014 |
| Visit: | https://www.zymergen.com/ |

PanTher Therapeutics
PanTher is developing treatments for solid tumors through minimally invasive implantable modalities for localized cancer therapy.
| Industry: | Drug Delivery |
| Status: | Active |
| Initial Investment: | 2017 |
| Visit: | https://www.panthertx.com/ |

EpiBiologics
Developing antibody based targeted therapies against membrane and extracellular proteins that drive underlying disease biology.
| Industry: | Therapeutics |
| Status: | Active |
| Initial Investment: | 2021 |
| Visit: | https://www.epibiologics.com/ |











